BiopestPeptidV1, Main, Exploration, bibRecord, 000584

Anti-Inflammatory Activity of β-thymosin Peptide Derived from Pacific Oyster (Crassostrea gigas) on NO and PGE₂ Production by Down-Regulating NF-κB in LPS-Induced RAW264.7 Macrophage Cells.

Identifieur interne : 000584 ( Main/Exploration ); précédent : 000583; suivant : 000585

Anti-Inflammatory Activity of β-thymosin Peptide Derived from Pacific Oyster (Crassostrea gigas) on NO and PGE₂ Production by Down-Regulating NF-κB in LPS-Induced RAW264.7 Macrophage Cells.

Auteurs : Dukhyun Hwang [Corée du Sud] ; Min-Jae Kang [Corée du Sud] ; Mi Jeong Jo [Corée du Sud] ; Yong Bae Seo [Corée du Sud] ; Nam Gyu Park [Corée du Sud] ; Gun-Do Kim [Corée du Sud]

Source :

Marine drugs [ 1660-3397 ] ; 2019.

RBID : pubmed:30795639

Descripteurs français

KwdFr :
- Alignement de séquences (MeSH), Animaux (MeSH), Anti-inflammatoires (pharmacologie), Cellules RAW 264.7 (MeSH), Cellules cultivées (MeSH), Crassostrea (composition chimique), Cyclooxygenase 2 (métabolisme), Dinoprostone (biosynthèse), Dinoprostone (métabolisme), Facteur de nécrose tumorale alpha (métabolisme), Facteur de transcription NF-kappa B (métabolisme), Humains (MeSH), Interleukine-1 bêta (métabolisme), Interleukine-6 (métabolisme), Kératinocytes (effets des médicaments et des substances chimiques), Lipopolysaccharides (pharmacologie), Macrophages (effets des médicaments et des substances chimiques), Macrophages (métabolisme), Monoxyde d'azote (biosynthèse), Monoxyde d'azote (métabolisme), Nitric oxide synthase type II (métabolisme), Souris (MeSH), Survie cellulaire (MeSH), Thymosine (isolement et purification), Thymosine (pharmacologie), Transduction du signal (effets des médicaments et des substances chimiques).
MESH :
- biosynthèse : Dinoprostone, Monoxyde d'azote.
- composition chimique : Crassostrea.
- effets des médicaments et des substances chimiques : Kératinocytes, Macrophages, Transduction du signal.
- isolement et purification : Thymosine.
- métabolisme : Cyclooxygenase 2, Dinoprostone, Facteur de nécrose tumorale alpha, Facteur de transcription NF-kappa B, Interleukine-1 bêta, Interleukine-6, Macrophages, Monoxyde d'azote, Nitric oxide synthase type II.
- pharmacologie : Anti-inflammatoires, Lipopolysaccharides, Thymosine.
- Alignement de séquences, Animaux, Cellules RAW 264.7, Cellules cultivées, Humains, Souris, Survie cellulaire.

English descriptors

KwdEn :
- Animals (MeSH), Anti-Inflammatory Agents (pharmacology), Cell Survival (MeSH), Cells, Cultured (MeSH), Crassostrea (chemistry), Cyclooxygenase 2 (metabolism), Dinoprostone (biosynthesis), Dinoprostone (metabolism), Humans (MeSH), Interleukin-1beta (metabolism), Interleukin-6 (metabolism), Keratinocytes (drug effects), Lipopolysaccharides (pharmacology), Macrophages (drug effects), Macrophages (metabolism), Mice (MeSH), NF-kappa B (metabolism), Nitric Oxide (biosynthesis), Nitric Oxide (metabolism), Nitric Oxide Synthase Type II (metabolism), RAW 264.7 Cells (MeSH), Sequence Alignment (MeSH), Signal Transduction (drug effects), Thymosin (isolation & purification), Thymosin (pharmacology), Tumor Necrosis Factor-alpha (metabolism).
MESH :
- chemical , biosynthesis : Dinoprostone, Nitric Oxide.
- chemical , isolation & purification : Thymosin.
- chemical , metabolism : Cyclooxygenase 2, Dinoprostone, Interleukin-1beta, Interleukin-6, NF-kappa B, Nitric Oxide, Nitric Oxide Synthase Type II, Tumor Necrosis Factor-alpha.
- chemical , pharmacology : Anti-Inflammatory Agents, Lipopolysaccharides, Thymosin.
- chemistry : Crassostrea.
- drug effects : Keratinocytes, Macrophages, Signal Transduction.
- metabolism : Macrophages.
- Animals, Cell Survival, Cells, Cultured, Humans, Mice, RAW 264.7 Cells, Sequence Alignment.

Abstract

β-thymosin is known for having 43 amino acids, being water-soluble, having a light molecular weight and ubiquitous polypeptide. The biological activities of β-thymosin are diverse and include the promotion of wound healing, reduction of inflammation, differentiation of T cells and inhibition of apoptosis. Our previous studies showed that oyster β-thymosin originated from the mantle of the Pacific oyster, Crassostrea gigas and had antimicrobial activity. In this study, we investigated the anti-inflammatory effects of oyster β-thymosin in lipopolysaccharide (LPS)-induced RAW264.7 macrophage cells using human β-thymosin as a control. Oyster β-thymosin inhibited the nitric oxide (NO) production as much as human β-thymosin in LPS-induced RAW264.7 cells. It also showed that oyster β-thymosin suppressed the expression of prostaglandin E₂ (PGE₂), inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2). Moreover, oyster β-thymosin reduced inflammatory cytokines such as tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β) and interleukin-6 (IL-6). Oyster β-thymosin also suppressed the nuclear translocation of phosphorylated nuclear factor-κB (NF-κB) and degradation of inhibitory κB (IκB) in LPS-induced RAW264.7 cells. These results suggest that oyster β-thymosin, which is derived from the mantle of the Pacific oyster, has as much anti-inflammatory effects as human β-thymosin. Additionally, oyster β-thymosin suppressed NO production, PGE₂ production and inflammatory cytokines expression via NF-κB in LPS-induced RAW264.7 cells.

DOI: 10.3390/md17020129
PubMed: 30795639
PubMed Central: PMC6409780

Affiliations:

Corée du Sud

Links toward previous steps (curation, corpus...)

to stream Main, to step Corpus: 000467
to stream Main, to step Curation: 000467

Le document en format XML

<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Anti-Inflammatory Activity of β-thymosin Peptide Derived from Pacific Oyster (<i>Crassostrea gigas</i>
) on NO and PGE₂ Production by Down-Regulating NF-κB in LPS-Induced RAW264.7 Macrophage Cells.</title>
<author><name sortKey="Hwang, Dukhyun" sort="Hwang, Dukhyun" uniqKey="Hwang D" first="Dukhyun" last="Hwang">Dukhyun Hwang</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Microbiology, College of Natural Sciences, Pukyong National University, Busan 48513, Korea. amitie725@naver.com.</nlm:affiliation>
<country xml:lang="fr">Corée du Sud</country>
<wicri:regionArea>Department of Microbiology, College of Natural Sciences, Pukyong National University, Busan 48513</wicri:regionArea>
<wicri:noRegion>Busan 48513</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Kang, Min Jae" sort="Kang, Min Jae" uniqKey="Kang M" first="Min-Jae" last="Kang">Min-Jae Kang</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Microbiology, College of Natural Sciences, Pukyong National University, Busan 48513, Korea. rkdalsrbmc@naver.com.</nlm:affiliation>
<country xml:lang="fr">Corée du Sud</country>
<wicri:regionArea>Department of Microbiology, College of Natural Sciences, Pukyong National University, Busan 48513</wicri:regionArea>
<wicri:noRegion>Busan 48513</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Jo, Mi Jeong" sort="Jo, Mi Jeong" uniqKey="Jo M" first="Mi Jeong" last="Jo">Mi Jeong Jo</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Microbiology, College of Natural Sciences, Pukyong National University, Busan 48513, Korea. miss5274@naver.com.</nlm:affiliation>
<country xml:lang="fr">Corée du Sud</country>
<wicri:regionArea>Department of Microbiology, College of Natural Sciences, Pukyong National University, Busan 48513</wicri:regionArea>
<wicri:noRegion>Busan 48513</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Seo, Yong Bae" sort="Seo, Yong Bae" uniqKey="Seo Y" first="Yong Bae" last="Seo">Yong Bae Seo</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Microbiology, College of Natural Sciences, Pukyong National University, Busan 48513, Korea. haehoo76@pknu.ac.kr.</nlm:affiliation>
<country xml:lang="fr">Corée du Sud</country>
<wicri:regionArea>Department of Microbiology, College of Natural Sciences, Pukyong National University, Busan 48513</wicri:regionArea>
<wicri:noRegion>Busan 48513</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Park, Nam Gyu" sort="Park, Nam Gyu" uniqKey="Park N" first="Nam Gyu" last="Park">Nam Gyu Park</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Biotechnology, College of Fishery Sciences, Pukyong National University, Busan 48513, Korea. ngpark@pknu.ac.kr.</nlm:affiliation>
<country xml:lang="fr">Corée du Sud</country>
<wicri:regionArea>Department of Biotechnology, College of Fishery Sciences, Pukyong National University, Busan 48513</wicri:regionArea>
<wicri:noRegion>Busan 48513</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Kim, Gun Do" sort="Kim, Gun Do" uniqKey="Kim G" first="Gun-Do" last="Kim">Gun-Do Kim</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Microbiology, College of Natural Sciences, Pukyong National University, Busan 48513, Korea. gundokim@pknu.ac.kr.</nlm:affiliation>
<country xml:lang="fr">Corée du Sud</country>
<wicri:regionArea>Department of Microbiology, College of Natural Sciences, Pukyong National University, Busan 48513</wicri:regionArea>
<wicri:noRegion>Busan 48513</wicri:noRegion>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PubMed</idno>
<date when="2019">2019</date>
<idno type="RBID">pubmed:30795639</idno>
<idno type="pmid">30795639</idno>
<idno type="doi">10.3390/md17020129</idno>
<idno type="pmc">PMC6409780</idno>
<idno type="wicri:Area/Main/Corpus">000467</idno>
<idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Corpus" wicri:corpus="PubMed">000467</idno>
<idno type="wicri:Area/Main/Curation">000467</idno>
<idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Curation">000467</idno>
<idno type="wicri:Area/Main/Exploration">000467</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en">Anti-Inflammatory Activity of β-thymosin Peptide Derived from Pacific Oyster (<i>Crassostrea gigas</i>
) on NO and PGE₂ Production by Down-Regulating NF-κB in LPS-Induced RAW264.7 Macrophage Cells.</title>
<author><name sortKey="Hwang, Dukhyun" sort="Hwang, Dukhyun" uniqKey="Hwang D" first="Dukhyun" last="Hwang">Dukhyun Hwang</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Microbiology, College of Natural Sciences, Pukyong National University, Busan 48513, Korea. amitie725@naver.com.</nlm:affiliation>
<country xml:lang="fr">Corée du Sud</country>
<wicri:regionArea>Department of Microbiology, College of Natural Sciences, Pukyong National University, Busan 48513</wicri:regionArea>
<wicri:noRegion>Busan 48513</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Kang, Min Jae" sort="Kang, Min Jae" uniqKey="Kang M" first="Min-Jae" last="Kang">Min-Jae Kang</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Microbiology, College of Natural Sciences, Pukyong National University, Busan 48513, Korea. rkdalsrbmc@naver.com.</nlm:affiliation>
<country xml:lang="fr">Corée du Sud</country>
<wicri:regionArea>Department of Microbiology, College of Natural Sciences, Pukyong National University, Busan 48513</wicri:regionArea>
<wicri:noRegion>Busan 48513</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Jo, Mi Jeong" sort="Jo, Mi Jeong" uniqKey="Jo M" first="Mi Jeong" last="Jo">Mi Jeong Jo</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Microbiology, College of Natural Sciences, Pukyong National University, Busan 48513, Korea. miss5274@naver.com.</nlm:affiliation>
<country xml:lang="fr">Corée du Sud</country>
<wicri:regionArea>Department of Microbiology, College of Natural Sciences, Pukyong National University, Busan 48513</wicri:regionArea>
<wicri:noRegion>Busan 48513</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Seo, Yong Bae" sort="Seo, Yong Bae" uniqKey="Seo Y" first="Yong Bae" last="Seo">Yong Bae Seo</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Microbiology, College of Natural Sciences, Pukyong National University, Busan 48513, Korea. haehoo76@pknu.ac.kr.</nlm:affiliation>
<country xml:lang="fr">Corée du Sud</country>
<wicri:regionArea>Department of Microbiology, College of Natural Sciences, Pukyong National University, Busan 48513</wicri:regionArea>
<wicri:noRegion>Busan 48513</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Park, Nam Gyu" sort="Park, Nam Gyu" uniqKey="Park N" first="Nam Gyu" last="Park">Nam Gyu Park</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Biotechnology, College of Fishery Sciences, Pukyong National University, Busan 48513, Korea. ngpark@pknu.ac.kr.</nlm:affiliation>
<country xml:lang="fr">Corée du Sud</country>
<wicri:regionArea>Department of Biotechnology, College of Fishery Sciences, Pukyong National University, Busan 48513</wicri:regionArea>
<wicri:noRegion>Busan 48513</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Kim, Gun Do" sort="Kim, Gun Do" uniqKey="Kim G" first="Gun-Do" last="Kim">Gun-Do Kim</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Microbiology, College of Natural Sciences, Pukyong National University, Busan 48513, Korea. gundokim@pknu.ac.kr.</nlm:affiliation>
<country xml:lang="fr">Corée du Sud</country>
<wicri:regionArea>Department of Microbiology, College of Natural Sciences, Pukyong National University, Busan 48513</wicri:regionArea>
<wicri:noRegion>Busan 48513</wicri:noRegion>
</affiliation>
</author>
</analytic>
<series><title level="j">Marine drugs</title>
<idno type="eISSN">1660-3397</idno>
<imprint><date when="2019" type="published">2019</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals (MeSH)</term>
<term>Anti-Inflammatory Agents (pharmacology)</term>
<term>Cell Survival (MeSH)</term>
<term>Cells, Cultured (MeSH)</term>
<term>Crassostrea (chemistry)</term>
<term>Cyclooxygenase 2 (metabolism)</term>
<term>Dinoprostone (biosynthesis)</term>
<term>Dinoprostone (metabolism)</term>
<term>Humans (MeSH)</term>
<term>Interleukin-1beta (metabolism)</term>
<term>Interleukin-6 (metabolism)</term>
<term>Keratinocytes (drug effects)</term>
<term>Lipopolysaccharides (pharmacology)</term>
<term>Macrophages (drug effects)</term>
<term>Macrophages (metabolism)</term>
<term>Mice (MeSH)</term>
<term>NF-kappa B (metabolism)</term>
<term>Nitric Oxide (biosynthesis)</term>
<term>Nitric Oxide (metabolism)</term>
<term>Nitric Oxide Synthase Type II (metabolism)</term>
<term>RAW 264.7 Cells (MeSH)</term>
<term>Sequence Alignment (MeSH)</term>
<term>Signal Transduction (drug effects)</term>
<term>Thymosin (isolation & purification)</term>
<term>Thymosin (pharmacology)</term>
<term>Tumor Necrosis Factor-alpha (metabolism)</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Alignement de séquences (MeSH)</term>
<term>Animaux (MeSH)</term>
<term>Anti-inflammatoires (pharmacologie)</term>
<term>Cellules RAW 264.7 (MeSH)</term>
<term>Cellules cultivées (MeSH)</term>
<term>Crassostrea (composition chimique)</term>
<term>Cyclooxygenase 2 (métabolisme)</term>
<term>Dinoprostone (biosynthèse)</term>
<term>Dinoprostone (métabolisme)</term>
<term>Facteur de nécrose tumorale alpha (métabolisme)</term>
<term>Facteur de transcription NF-kappa B (métabolisme)</term>
<term>Humains (MeSH)</term>
<term>Interleukine-1 bêta (métabolisme)</term>
<term>Interleukine-6 (métabolisme)</term>
<term>Kératinocytes (effets des médicaments et des substances chimiques)</term>
<term>Lipopolysaccharides (pharmacologie)</term>
<term>Macrophages (effets des médicaments et des substances chimiques)</term>
<term>Macrophages (métabolisme)</term>
<term>Monoxyde d'azote (biosynthèse)</term>
<term>Monoxyde d'azote (métabolisme)</term>
<term>Nitric oxide synthase type II (métabolisme)</term>
<term>Souris (MeSH)</term>
<term>Survie cellulaire (MeSH)</term>
<term>Thymosine (isolement et purification)</term>
<term>Thymosine (pharmacologie)</term>
<term>Transduction du signal (effets des médicaments et des substances chimiques)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="biosynthesis" xml:lang="en"><term>Dinoprostone</term>
<term>Nitric Oxide</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="isolation & purification" xml:lang="en"><term>Thymosin</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Cyclooxygenase 2</term>
<term>Dinoprostone</term>
<term>Interleukin-1beta</term>
<term>Interleukin-6</term>
<term>NF-kappa B</term>
<term>Nitric Oxide</term>
<term>Nitric Oxide Synthase Type II</term>
<term>Tumor Necrosis Factor-alpha</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Anti-Inflammatory Agents</term>
<term>Lipopolysaccharides</term>
<term>Thymosin</term>
</keywords>
<keywords scheme="MESH" qualifier="biosynthèse" xml:lang="fr"><term>Dinoprostone</term>
<term>Monoxyde d'azote</term>
</keywords>
<keywords scheme="MESH" qualifier="chemistry" xml:lang="en"><term>Crassostrea</term>
</keywords>
<keywords scheme="MESH" qualifier="composition chimique" xml:lang="fr"><term>Crassostrea</term>
</keywords>
<keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Keratinocytes</term>
<term>Macrophages</term>
<term>Signal Transduction</term>
</keywords>
<keywords scheme="MESH" qualifier="effets des médicaments et des substances chimiques" xml:lang="fr"><term>Kératinocytes</term>
<term>Macrophages</term>
<term>Transduction du signal</term>
</keywords>
<keywords scheme="MESH" qualifier="isolement et purification" xml:lang="fr"><term>Thymosine</term>
</keywords>
<keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Macrophages</term>
</keywords>
<keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Cyclooxygenase 2</term>
<term>Dinoprostone</term>
<term>Facteur de nécrose tumorale alpha</term>
<term>Facteur de transcription NF-kappa B</term>
<term>Interleukine-1 bêta</term>
<term>Interleukine-6</term>
<term>Macrophages</term>
<term>Monoxyde d'azote</term>
<term>Nitric oxide synthase type II</term>
</keywords>
<keywords scheme="MESH" qualifier="pharmacologie" xml:lang="fr"><term>Anti-inflammatoires</term>
<term>Lipopolysaccharides</term>
<term>Thymosine</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Animals</term>
<term>Cell Survival</term>
<term>Cells, Cultured</term>
<term>Humans</term>
<term>Mice</term>
<term>RAW 264.7 Cells</term>
<term>Sequence Alignment</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Alignement de séquences</term>
<term>Animaux</term>
<term>Cellules RAW 264.7</term>
<term>Cellules cultivées</term>
<term>Humains</term>
<term>Souris</term>
<term>Survie cellulaire</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">β-thymosin is known for having 43 amino acids, being water-soluble, having a light molecular weight and ubiquitous polypeptide. The biological activities of β-thymosin are diverse and include the promotion of wound healing, reduction of inflammation, differentiation of T cells and inhibition of apoptosis. Our previous studies showed that oyster β-thymosin originated from the mantle of the Pacific oyster, <i>Crassostrea gigas</i>
 and had antimicrobial activity. In this study, we investigated the anti-inflammatory effects of oyster β-thymosin in lipopolysaccharide (LPS)-induced RAW264.7 macrophage cells using human β-thymosin as a control. Oyster β-thymosin inhibited the nitric oxide (NO) production as much as human β-thymosin in LPS-induced RAW264.7 cells. It also showed that oyster β-thymosin suppressed the expression of prostaglandin E₂ (PGE₂), inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2). Moreover, oyster β-thymosin reduced inflammatory cytokines such as tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β) and interleukin-6 (IL-6). Oyster β-thymosin also suppressed the nuclear translocation of phosphorylated nuclear factor-κB (NF-κB) and degradation of inhibitory κB (IκB) in LPS-induced RAW264.7 cells. These results suggest that oyster β-thymosin, which is derived from the mantle of the Pacific oyster, has as much anti-inflammatory effects as human β-thymosin. Additionally, oyster β-thymosin suppressed NO production, PGE₂ production and inflammatory cytokines expression via NF-κB in LPS-induced RAW264.7 cells.</div>
</front>
</TEI>
<pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">30795639</PMID>
<DateCompleted><Year>2019</Year>
<Month>07</Month>
<Day>22</Day>
</DateCompleted>
<DateRevised><Year>2020</Year>
<Month>02</Month>
<Day>25</Day>
</DateRevised>
<Article PubModel="Electronic"><Journal><ISSN IssnType="Electronic">1660-3397</ISSN>
<JournalIssue CitedMedium="Internet"><Volume>17</Volume>
<Issue>2</Issue>
<PubDate><Year>2019</Year>
<Month>Feb</Month>
<Day>21</Day>
</PubDate>
</JournalIssue>
<Title>Marine drugs</Title>
<ISOAbbreviation>Mar Drugs</ISOAbbreviation>
</Journal>
<ArticleTitle>Anti-Inflammatory Activity of β-thymosin Peptide Derived from Pacific Oyster (<i>Crassostrea gigas</i>
) on NO and PGE₂ Production by Down-Regulating NF-κB in LPS-Induced RAW264.7 Macrophage Cells.</ArticleTitle>
<ELocationID EIdType="pii" ValidYN="Y">E129</ELocationID>
<ELocationID EIdType="doi" ValidYN="Y">10.3390/md17020129</ELocationID>
<Abstract><AbstractText>β-thymosin is known for having 43 amino acids, being water-soluble, having a light molecular weight and ubiquitous polypeptide. The biological activities of β-thymosin are diverse and include the promotion of wound healing, reduction of inflammation, differentiation of T cells and inhibition of apoptosis. Our previous studies showed that oyster β-thymosin originated from the mantle of the Pacific oyster, <i>Crassostrea gigas</i>
 and had antimicrobial activity. In this study, we investigated the anti-inflammatory effects of oyster β-thymosin in lipopolysaccharide (LPS)-induced RAW264.7 macrophage cells using human β-thymosin as a control. Oyster β-thymosin inhibited the nitric oxide (NO) production as much as human β-thymosin in LPS-induced RAW264.7 cells. It also showed that oyster β-thymosin suppressed the expression of prostaglandin E₂ (PGE₂), inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2). Moreover, oyster β-thymosin reduced inflammatory cytokines such as tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β) and interleukin-6 (IL-6). Oyster β-thymosin also suppressed the nuclear translocation of phosphorylated nuclear factor-κB (NF-κB) and degradation of inhibitory κB (IκB) in LPS-induced RAW264.7 cells. These results suggest that oyster β-thymosin, which is derived from the mantle of the Pacific oyster, has as much anti-inflammatory effects as human β-thymosin. Additionally, oyster β-thymosin suppressed NO production, PGE₂ production and inflammatory cytokines expression via NF-κB in LPS-induced RAW264.7 cells.</AbstractText>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Hwang</LastName>
<ForeName>Dukhyun</ForeName>
<Initials>D</Initials>
<AffiliationInfo><Affiliation>Department of Microbiology, College of Natural Sciences, Pukyong National University, Busan 48513, Korea. amitie725@naver.com.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Kang</LastName>
<ForeName>Min-Jae</ForeName>
<Initials>MJ</Initials>
<AffiliationInfo><Affiliation>Department of Microbiology, College of Natural Sciences, Pukyong National University, Busan 48513, Korea. rkdalsrbmc@naver.com.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Jo</LastName>
<ForeName>Mi Jeong</ForeName>
<Initials>MJ</Initials>
<Identifier Source="ORCID">0000-0001-7289-6203</Identifier>
<AffiliationInfo><Affiliation>Department of Microbiology, College of Natural Sciences, Pukyong National University, Busan 48513, Korea. miss5274@naver.com.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Seo</LastName>
<ForeName>Yong Bae</ForeName>
<Initials>YB</Initials>
<AffiliationInfo><Affiliation>Department of Microbiology, College of Natural Sciences, Pukyong National University, Busan 48513, Korea. haehoo76@pknu.ac.kr.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Park</LastName>
<ForeName>Nam Gyu</ForeName>
<Initials>NG</Initials>
<AffiliationInfo><Affiliation>Department of Biotechnology, College of Fishery Sciences, Pukyong National University, Busan 48513, Korea. ngpark@pknu.ac.kr.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Kim</LastName>
<ForeName>Gun-Do</ForeName>
<Initials>GD</Initials>
<Identifier Source="ORCID">0000-0001-5965-0495</Identifier>
<AffiliationInfo><Affiliation>Department of Microbiology, College of Natural Sciences, Pukyong National University, Busan 48513, Korea. gundokim@pknu.ac.kr.</Affiliation>
</AffiliationInfo>
</Author>
</AuthorList>
<Language>eng</Language>
<GrantList CompleteYN="Y"><Grant><GrantID>NRF-2016R1A2B4014909</GrantID>
<Agency>National Research Foundation of Korea</Agency>
<Country></Country>
</Grant>
</GrantList>
<PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType>
</PublicationTypeList>
<ArticleDate DateType="Electronic"><Year>2019</Year>
<Month>02</Month>
<Day>21</Day>
</ArticleDate>
</Article>
<MedlineJournalInfo><Country>Switzerland</Country>
<MedlineTA>Mar Drugs</MedlineTA>
<NlmUniqueID>101213729</NlmUniqueID>
<ISSNLinking>1660-3397</ISSNLinking>
</MedlineJournalInfo>
<ChemicalList><Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D000893">Anti-Inflammatory Agents</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D053583">Interleukin-1beta</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D015850">Interleukin-6</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D008070">Lipopolysaccharides</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D016328">NF-kappa B</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D014409">Tumor Necrosis Factor-alpha</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>31C4KY9ESH</RegistryNumber>
<NameOfSubstance UI="D009569">Nitric Oxide</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>61512-21-8</RegistryNumber>
<NameOfSubstance UI="D013947">Thymosin</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>EC 1.14.13.39</RegistryNumber>
<NameOfSubstance UI="D052247">Nitric Oxide Synthase Type II</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>EC 1.14.99.1</RegistryNumber>
<NameOfSubstance UI="D051546">Cyclooxygenase 2</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>K7Q1JQR04M</RegistryNumber>
<NameOfSubstance UI="D015232">Dinoprostone</NameOfSubstance>
</Chemical>
</ChemicalList>
<CitationSubset>IM</CitationSubset>
<MeshHeadingList><MeshHeading><DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D000893" MajorTopicYN="N">Anti-Inflammatory Agents</DescriptorName>
<QualifierName UI="Q000494" MajorTopicYN="Y">pharmacology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D002470" MajorTopicYN="N">Cell Survival</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D002478" MajorTopicYN="N">Cells, Cultured</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D049896" MajorTopicYN="N">Crassostrea</DescriptorName>
<QualifierName UI="Q000737" MajorTopicYN="Y">chemistry</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D051546" MajorTopicYN="N">Cyclooxygenase 2</DescriptorName>
<QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D015232" MajorTopicYN="N">Dinoprostone</DescriptorName>
<QualifierName UI="Q000096" MajorTopicYN="Y">biosynthesis</QualifierName>
<QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D053583" MajorTopicYN="N">Interleukin-1beta</DescriptorName>
<QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D015850" MajorTopicYN="N">Interleukin-6</DescriptorName>
<QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D015603" MajorTopicYN="N">Keratinocytes</DescriptorName>
<QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D008070" MajorTopicYN="N">Lipopolysaccharides</DescriptorName>
<QualifierName UI="Q000494" MajorTopicYN="N">pharmacology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D008264" MajorTopicYN="N">Macrophages</DescriptorName>
<QualifierName UI="Q000187" MajorTopicYN="Y">drug effects</QualifierName>
<QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D051379" MajorTopicYN="N">Mice</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D016328" MajorTopicYN="N">NF-kappa B</DescriptorName>
<QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D009569" MajorTopicYN="N">Nitric Oxide</DescriptorName>
<QualifierName UI="Q000096" MajorTopicYN="Y">biosynthesis</QualifierName>
<QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D052247" MajorTopicYN="N">Nitric Oxide Synthase Type II</DescriptorName>
<QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D000067996" MajorTopicYN="N">RAW 264.7 Cells</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D016415" MajorTopicYN="N">Sequence Alignment</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D015398" MajorTopicYN="N">Signal Transduction</DescriptorName>
<QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D013947" MajorTopicYN="N">Thymosin</DescriptorName>
<QualifierName UI="Q000302" MajorTopicYN="N">isolation & purification</QualifierName>
<QualifierName UI="Q000494" MajorTopicYN="Y">pharmacology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D014409" MajorTopicYN="N">Tumor Necrosis Factor-alpha</DescriptorName>
<QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName>
</MeshHeading>
</MeshHeadingList>
<KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">NF-κB</Keyword>
<Keyword MajorTopicYN="N">Pacific oyster (Crassostrea gigas)</Keyword>
<Keyword MajorTopicYN="N">RAW264.7 cells</Keyword>
<Keyword MajorTopicYN="N">cytokines</Keyword>
<Keyword MajorTopicYN="N">nitric oxide</Keyword>
<Keyword MajorTopicYN="N">prostaglandin E2</Keyword>
<Keyword MajorTopicYN="N">β-thymosin</Keyword>
</KeywordList>
</MedlineCitation>
<PubmedData><History><PubMedPubDate PubStatus="received"><Year>2018</Year>
<Month>12</Month>
<Day>21</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="revised"><Year>2019</Year>
<Month>02</Month>
<Day>04</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="accepted"><Year>2019</Year>
<Month>02</Month>
<Day>18</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="entrez"><Year>2019</Year>
<Month>2</Month>
<Day>24</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
<PubMedPubDate PubStatus="pubmed"><Year>2019</Year>
<Month>2</Month>
<Day>24</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
<PubMedPubDate PubStatus="medline"><Year>2019</Year>
<Month>7</Month>
<Day>23</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
</History>
<PublicationStatus>epublish</PublicationStatus>
<ArticleIdList><ArticleId IdType="pubmed">30795639</ArticleId>
<ArticleId IdType="pii">md17020129</ArticleId>
<ArticleId IdType="doi">10.3390/md17020129</ArticleId>
<ArticleId IdType="pmc">PMC6409780</ArticleId>
</ArticleIdList>
<ReferenceList><Reference><Citation>Am J Physiol. 1999 Jun;276(6):G1313-6</Citation>
<ArticleIdList><ArticleId IdType="pubmed">10362633</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Oncogene. 1999 Dec 20;18(55):7908-16</Citation>
<ArticleIdList><ArticleId IdType="pubmed">10630643</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Fitoterapia. 2000 Aug;71 Suppl 1:S48-57</Citation>
<ArticleIdList><ArticleId IdType="pubmed">10930713</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Curr Opin Chem Biol. 2000 Dec;4(6):687-95</Citation>
<ArticleIdList><ArticleId IdType="pubmed">11102875</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Clin Invest. 2001 Jan;107(1):7-11</Citation>
<ArticleIdList><ArticleId IdType="pubmed">11134171</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Exp Eye Res. 2002 Feb;74(2):293-9</Citation>
<ArticleIdList><ArticleId IdType="pubmed">11950239</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Nat Rev Immunol. 2002 Oct;2(10):787-95</Citation>
<ArticleIdList><ArticleId IdType="pubmed">12360216</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Nat Rev Immunol. 2003 Jan;3(1):23-35</Citation>
<ArticleIdList><ArticleId IdType="pubmed">12511873</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Kidney Int. 2005 Apr;67(4):1216-33</Citation>
<ArticleIdList><ArticleId IdType="pubmed">15780075</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Curr Drug Targets Inflamm Allergy. 2005 Aug;4(4):471-9</Citation>
<ArticleIdList><ArticleId IdType="pubmed">16101524</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Biol Chem. 2006 Jan 6;281(1):313-23</Citation>
<ArticleIdList><ArticleId IdType="pubmed">16246846</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Cell. 2006 Feb 24;124(4):783-801</Citation>
<ArticleIdList><ArticleId IdType="pubmed">16497588</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Exp Eye Res. 2007 Apr;84(4):663-9</Citation>
<ArticleIdList><ArticleId IdType="pubmed">17254567</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Trends Mol Med. 2007 Nov;13(11):460-9</Citation>
<ArticleIdList><ArticleId IdType="pubmed">18029230</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Biochem Pharmacol. 2009 Sep 15;78(6):539-52</Citation>
<ArticleIdList><ArticleId IdType="pubmed">19413999</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Dev Comp Immunol. 2009 Jul;33(7):867-76</Citation>
<ArticleIdList><ArticleId IdType="pubmed">19428488</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Fish Shellfish Immunol. 2009 Aug;27(2):379-82</Citation>
<ArticleIdList><ArticleId IdType="pubmed">19524680</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Cell. 2010 Mar 19;140(6):883-99</Citation>
<ArticleIdList><ArticleId IdType="pubmed">20303878</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Arterioscler Thromb Vasc Biol. 2011 May;31(5):986-1000</Citation>
<ArticleIdList><ArticleId IdType="pubmed">21508345</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>PLoS One. 2011;6(8):e23142</Citation>
<ArticleIdList><ArticleId IdType="pubmed">21829707</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Mediators Inflamm. 2012;2012:327568</Citation>
<ArticleIdList><ArticleId IdType="pubmed">23024463</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Mol Cell Biochem. 2013 Sep;381(1-2):283-90</Citation>
<ArticleIdList><ArticleId IdType="pubmed">23749167</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Nucleic Acids Res. 2014 Jul;42(Web Server issue):W320-4</Citation>
<ArticleIdList><ArticleId IdType="pubmed">24753421</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Fish Shellfish Immunol. 2015 Jul;45(1):167-74</Citation>
<ArticleIdList><ArticleId IdType="pubmed">25842181</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Pharm Pharmacol. 2015 Sep;67(9):1297-305</Citation>
<ArticleIdList><ArticleId IdType="pubmed">25904113</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>PLoS One. 2016 Jan 20;11(1):e0146708</Citation>
<ArticleIdList><ArticleId IdType="pubmed">26789270</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Int J Neurosci. 2017 Jul;127(7):624-633</Citation>
<ArticleIdList><ArticleId IdType="pubmed">27412492</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Mar Drugs. 2017 Sep 02;15(9):null</Citation>
<ArticleIdList><ArticleId IdType="pubmed">28869509</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Expert Opin Biol Ther. 2018 Jul;18(sup1):193-197</Citation>
<ArticleIdList><ArticleId IdType="pubmed">29508629</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Vet World. 2018 May;11(5):627-635</Citation>
<ArticleIdList><ArticleId IdType="pubmed">29915501</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Int J Mol Sci. 2018 Nov 29;19(12):null</Citation>
<ArticleIdList><ArticleId IdType="pubmed">30501075</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>FASEB J. 1995 Oct;9(13):1319-30</Citation>
<ArticleIdList><ArticleId IdType="pubmed">7557022</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Proc Soc Exp Biol Med. 1995 Nov;210(2):93-101</Citation>
<ArticleIdList><ArticleId IdType="pubmed">7568290</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Leukoc Biol. 1996 Jul;60(1):8-26</Citation>
<ArticleIdList><ArticleId IdType="pubmed">8699127</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Proc Natl Acad Sci U S A. 1999 Jan 5;96(1):272-7</Citation>
<ArticleIdList><ArticleId IdType="pubmed">9874808</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
</PubmedData>
</pubmed>
<affiliations><list><country><li>Corée du Sud</li>
</country>
</list>
<tree><country name="Corée du Sud"><noRegion><name sortKey="Hwang, Dukhyun" sort="Hwang, Dukhyun" uniqKey="Hwang D" first="Dukhyun" last="Hwang">Dukhyun Hwang</name>
</noRegion>
<name sortKey="Jo, Mi Jeong" sort="Jo, Mi Jeong" uniqKey="Jo M" first="Mi Jeong" last="Jo">Mi Jeong Jo</name>
<name sortKey="Kang, Min Jae" sort="Kang, Min Jae" uniqKey="Kang M" first="Min-Jae" last="Kang">Min-Jae Kang</name>
<name sortKey="Kim, Gun Do" sort="Kim, Gun Do" uniqKey="Kim G" first="Gun-Do" last="Kim">Gun-Do Kim</name>
<name sortKey="Park, Nam Gyu" sort="Park, Nam Gyu" uniqKey="Park N" first="Nam Gyu" last="Park">Nam Gyu Park</name>
<name sortKey="Seo, Yong Bae" sort="Seo, Yong Bae" uniqKey="Seo Y" first="Yong Bae" last="Seo">Yong Bae Seo</name>
</country>
</tree>
</affiliations>
</record>

Pour manipuler ce document sous Unix (Dilib)

EXPLOR_STEP=$WICRI_ROOT/Bois/explor/BiopestPeptidV1/Data/Main/Exploration

HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000584 | SxmlIndent | more

HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 000584 | SxmlIndent | more

Pour mettre un lien sur cette page dans le réseau Wicri

{{Explor lien
   |wiki=    Bois
   |area=    BiopestPeptidV1
   |flux=    Main
   |étape=   Exploration
   |type=    RBID
   |clé=     pubmed:30795639
   |texte=   Anti-Inflammatory Activity of β-thymosin Peptide Derived from Pacific Oyster (Crassostrea gigas) on NO and PGE₂ Production by Down-Regulating NF-κB in LPS-Induced RAW264.7 Macrophage Cells.
}}

Pour générer des pages wiki

HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i   -Sk "pubmed:30795639" \
       | HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd   \
       | NlmPubMed2Wicri -a BiopestPeptidV1

This area was generated with Dilib version V0.6.38.
Data generation: Thu Nov 19 19:22:35 2020. Site generation: Thu Nov 19 19:33:26 2020

	Serveur d'exploration sur les peptides biopesticides
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.

Serveur d'exploration sur les peptides biopesticides

Anti-Inflammatory Activity of β-thymosin Peptide Derived from Pacific Oyster (Crassostrea gigas) on NO and PGE₂ Production by Down-Regulating NF-κB in LPS-Induced RAW264.7 Macrophage Cells.

Anti-Inflammatory Activity of β-thymosin Peptide Derived from Pacific Oyster (Crassostrea gigas) on NO and PGE₂ Production by Down-Regulating NF-κB in LPS-Induced RAW264.7 Macrophage Cells.

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki